α-sinuklein fibril shakllanishini erta bosqichlarda to'xtatish PDni kuchayib borayotgan va patogen α-sinuklein fibrillarining hosil bo'lishini to'xtatish orqali kurashishning samarali yechimi bo'lishi mumkin. 🌟🧬🛡 https://www.sciencedirect.com/science/article/abs/pii/S1047847724000492
#ParkinsonsDisease #NeurodegenerativeDisorders #MolecularDynamics #Research #AlphaSynuclein #ElectricField #EarlyIntervention #ScientificDiscovery #HealthInnovation #BiomedicalResearch
#ParkinsonsDisease #NeurodegenerativeDisorders #MolecularDynamics #Research #AlphaSynuclein #ElectricField #EarlyIntervention #ScientificDiscovery #HealthInnovation #BiomedicalResearch
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[UZ] 🌟 Ilmiy tadqiqotlarimizdan ajoyib yangilik! 🌟
Alzheimer kasalligi (AD) bo‘yicha yangi tadqiqotimiz, dunyo bo‘ylab millionlab insonlarga ta'sir qiluvchi og‘ir nevrodejenerativ kasallik, Nature nashryotining Scientific Reports jurnalida chop etildi. 🧠✨
Ushbu tadqiqotda biz statik va o’zgaruvchan elektr maydonlari Alzheimer kasalligi bilan bog‘liq bo‘lgan zararli Aβ fibrillarini qanday buzishini o‘rgandik. Molekulyar dinamika simulyatsiyalari yordamida, toksikligi va barqaror tuzilishi bilan mashhur bo‘lgan Osaka mutatsiyasi (E22Δ) ga ega Aβ1–40 peptidining polimorfik fibril kompleksini tadqiq qildik.
Tadqiqot natijalarimiz shuni ko‘rsatadiki, 0.3–0.4 V/nm elektr maydoni va 0.20 GHz chastota bilan bu zararli fibrillarni samarali ravishda buzish mumkin. Bu yondashuv Alzheimer kasalligini davolash bo‘yicha yangi terapevtik usullarni ochib berishi mumkin. 🔬⚡️
Ushbu tadqiqotda ko‘rsatgan qimmatli hissalari uchun Dr. Artyom Baev (Ilg’or texnologiyalar markazi), Dr. Erkin S Kurganov (Broad Institute of MIT and Harvard), va fidoyi magistr talabam Muhriddin Mahkamovga katta rahmat aytaman.
To‘liq maqolani bu yerda o‘qing: https://www.nature.com/articles/s41598-024-72778-1
(Mana nima uchun mahalliy va xalqaro hamkorlik kerak!!!)
[EN] 🌟 Exciting Research Update! 🌟
Our latest study on Alzheimer’s disease (AD), a devastating neurodegenerative disorder affecting millions worldwide, has been published in Nature’s Scientific Reports. 🧠✨
In this research, we explored how static and oscillating electric fields can disrupt the harmful Aβ fibrils associated with AD. Using molecular dynamics simulations, we specifically examined a polymorphic fibrillar complex of the Aβ1–40 peptide with the Osaka mutation (E22Δ), which is known for its toxicity and stable structure.
Our findings reveal that applying a 0.3–0.4 V/nm electric field at a 0.20 GHz frequency can effectively disrupt these toxic fibrils, potentially offering a novel therapeutic approach to combating AD pathology. This is a promising step forward in understanding and addressing Alzheimer’s disease. 🔬⚡️
A huge thank you to Dr. Artyom Baev, Dr. Erkin Kurganov, and my dedicated student Mukhriddin Makhkamov for their valuable contributions to this work.
#AlzheimersResearch #NeurodegenerativeDisorders #MolecularDynamics #Therapeutics #ScientificReports #ElectricFields #ResearchInnovation #ADPathology
Alzheimer kasalligi (AD) bo‘yicha yangi tadqiqotimiz, dunyo bo‘ylab millionlab insonlarga ta'sir qiluvchi og‘ir nevrodejenerativ kasallik, Nature nashryotining Scientific Reports jurnalida chop etildi. 🧠✨
Ushbu tadqiqotda biz statik va o’zgaruvchan elektr maydonlari Alzheimer kasalligi bilan bog‘liq bo‘lgan zararli Aβ fibrillarini qanday buzishini o‘rgandik. Molekulyar dinamika simulyatsiyalari yordamida, toksikligi va barqaror tuzilishi bilan mashhur bo‘lgan Osaka mutatsiyasi (E22Δ) ga ega Aβ1–40 peptidining polimorfik fibril kompleksini tadqiq qildik.
Tadqiqot natijalarimiz shuni ko‘rsatadiki, 0.3–0.4 V/nm elektr maydoni va 0.20 GHz chastota bilan bu zararli fibrillarni samarali ravishda buzish mumkin. Bu yondashuv Alzheimer kasalligini davolash bo‘yicha yangi terapevtik usullarni ochib berishi mumkin. 🔬⚡️
Ushbu tadqiqotda ko‘rsatgan qimmatli hissalari uchun Dr. Artyom Baev (Ilg’or texnologiyalar markazi), Dr. Erkin S Kurganov (Broad Institute of MIT and Harvard), va fidoyi magistr talabam Muhriddin Mahkamovga katta rahmat aytaman.
To‘liq maqolani bu yerda o‘qing: https://www.nature.com/articles/s41598-024-72778-1
(Mana nima uchun mahalliy va xalqaro hamkorlik kerak!!!)
[EN] 🌟 Exciting Research Update! 🌟
Our latest study on Alzheimer’s disease (AD), a devastating neurodegenerative disorder affecting millions worldwide, has been published in Nature’s Scientific Reports. 🧠✨
In this research, we explored how static and oscillating electric fields can disrupt the harmful Aβ fibrils associated with AD. Using molecular dynamics simulations, we specifically examined a polymorphic fibrillar complex of the Aβ1–40 peptide with the Osaka mutation (E22Δ), which is known for its toxicity and stable structure.
Our findings reveal that applying a 0.3–0.4 V/nm electric field at a 0.20 GHz frequency can effectively disrupt these toxic fibrils, potentially offering a novel therapeutic approach to combating AD pathology. This is a promising step forward in understanding and addressing Alzheimer’s disease. 🔬⚡️
A huge thank you to Dr. Artyom Baev, Dr. Erkin Kurganov, and my dedicated student Mukhriddin Makhkamov for their valuable contributions to this work.
#AlzheimersResearch #NeurodegenerativeDisorders #MolecularDynamics #Therapeutics #ScientificReports #ElectricFields #ResearchInnovation #ADPathology
Nature
Understanding Osaka mutation polymorphic Aβ fibril response to static and oscillating electric fields: insights from computational…
Scientific Reports - Understanding Osaka mutation polymorphic Aβ fibril response to static and oscillating electric fields: insights from computational modeling
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