🧬📢 Navbatdagi hamkorlikdagi ilmiy maqolamiz ACS Journal of Chemical Information and Modeling jurnalida chop etildi! (IF- 5.7)🎉
Ushbu tadqiqot Center for Advanced Technologies - CAT Ilg'or texnologiyalar markazi - ITM olimlari bilan olib borayotgan mustahkam hamkorligimiz samarasidir. Ayniqsa, Artyom Baev rahbarligidagi guruhdagi iqtidorli yosh tadqiqotchi Khondamir Rustamovning o‘rni beqiyos — u sun’iy intellekt asosidagi molekulyar modellashtirish bo‘yicha ajoyib natijalarga erishib kelmoqda! 🚀🧠
🔍 Inson organizmidagi eng muhim o‘smaga qarshi oqsillardan biri — p53 o'rganildi. Bu oqsil saratonlarning 50% dan ortig‘ida mutatsiyaga uchraydi.
AlphaFold3, molekulyar dinamikaga asoslangan simulyatsiyalar orqali p53 ning 148 ta missens mutatsiyasini chuqur tahlil qilingan.
🔑 Tadqiqotdan asosiy natijalar:
- Ba’zi mutatsiyalar (masalan, R248P, N239S) DNK bilan bog‘lanish qobiliyatini kamaytiradi,
- Boshqalari (C238Y, P278R) esa bog‘lanishni kuchaytiradi, lekin sistemani beqarorlashtiradi,
- Qiziqarli tomoni shundaki, E285A, M243T kabi mutatsiyalar zararli ta’sirni kamaytirish (rescue) xususiyatiga ega bo‘lishi mumkin.
Tadqiqotimiz AI va hisoblash usullari yordamida saraton bilan bog‘liq molekulyar mexanizmlarni chuqur tushunishga imkon beradi 💡💊
🙏 Ushbu muhim tadqiqotda ishtirok etishga taklif qilgan hamkorlarim Artyom va Khondamirga chuqur minnatdorchilik bildiraman.
🧪🌍
🔗 https://pubs.acs.org/doi/abs/10.1021/acs.jcim.5c00580
#ACS #p53 #Cancer #AI #AlphaFold #moleculardynamics #ProteinChallenge #DNA
Ushbu tadqiqot Center for Advanced Technologies - CAT Ilg'or texnologiyalar markazi - ITM olimlari bilan olib borayotgan mustahkam hamkorligimiz samarasidir. Ayniqsa, Artyom Baev rahbarligidagi guruhdagi iqtidorli yosh tadqiqotchi Khondamir Rustamovning o‘rni beqiyos — u sun’iy intellekt asosidagi molekulyar modellashtirish bo‘yicha ajoyib natijalarga erishib kelmoqda! 🚀🧠
🔍 Inson organizmidagi eng muhim o‘smaga qarshi oqsillardan biri — p53 o'rganildi. Bu oqsil saratonlarning 50% dan ortig‘ida mutatsiyaga uchraydi.
AlphaFold3, molekulyar dinamikaga asoslangan simulyatsiyalar orqali p53 ning 148 ta missens mutatsiyasini chuqur tahlil qilingan.
🔑 Tadqiqotdan asosiy natijalar:
- Ba’zi mutatsiyalar (masalan, R248P, N239S) DNK bilan bog‘lanish qobiliyatini kamaytiradi,
- Boshqalari (C238Y, P278R) esa bog‘lanishni kuchaytiradi, lekin sistemani beqarorlashtiradi,
- Qiziqarli tomoni shundaki, E285A, M243T kabi mutatsiyalar zararli ta’sirni kamaytirish (rescue) xususiyatiga ega bo‘lishi mumkin.
Tadqiqotimiz AI va hisoblash usullari yordamida saraton bilan bog‘liq molekulyar mexanizmlarni chuqur tushunishga imkon beradi 💡💊
🙏 Ushbu muhim tadqiqotda ishtirok etishga taklif qilgan hamkorlarim Artyom va Khondamirga chuqur minnatdorchilik bildiraman.
🧪🌍
🔗 https://pubs.acs.org/doi/abs/10.1021/acs.jcim.5c00580
#ACS #p53 #Cancer #AI #AlphaFold #moleculardynamics #ProteinChallenge #DNA
ACS Publications
Investigation of Structural Mechanisms Underlying p53 Dysfunction Caused by 148 Missense Mutations Using AlphaFold3 and Molecular…
Tumor protein p53 (TP53) is a crucial regulator of genomic integrity, frequently mutated in more than half of all human cancers. These mutations predominantly target the DNA-binding domain (DBD), impairing p53’s interaction with DNA and its tumor-suppressive…
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[Uz]📢 Navbatdagi ilmiy maqolamiz Frontiers in Physics jurnalida chop etiladi! 📘🧠🎉
Ushbu tadqiqotda jamoamiz aʼzosi Dr. Tohir Akramov, magistrlar Muhriddin Maxkamov va Rasul Mashalov, shuningdek xalqaro hamkorlarimiz – Dr. Parthiban Marimuthu (Åbo Akademi Universiteti, Finlyandiya) va Dr. Aamir Shahzad (Pokiston, Faisalobod Davlat Universiteti) bilan birgalikda ish olib bordik. 🌍👨🔬
🔍 Nima oʻrganildi?
Ushbu tadqiqot Parkinson kasalligi bilan bogʻliq α-sinuklein oqsilining polimorf tuzilmasiga oksidlanish qanday ta’sir qilishini molekulyar darajada tahlil qildi.
🧬 Natijalar shuni ko‘rsatadiki, oksidlanish oqibatida ushbu oqsil tolalarining barqarorligi pasayadi, bu esa kasallik rivojlanishini oldini olishda muhim omil bo‘lishi mumkin.
🔬 Ushbu mexanizmlarni chuqur tushunish kelajakda davolash strategiyalarini ishlab chiqish uchun muhim asos bo‘lib xizmat qiladi.
🥳 Barcha hamkorlarga va ishtirokchilarga minnatdorchilik bildiraman – tabriklaymiz! 👏
[En] 📢 Our next research paper has been accepted for publication in Frontiers in Physics! 🎉📚
In this collaborative work, our team member Dr. Toxir Akramov, Master's students Mukhriddin Makhkamov and Mashalov Rasul, along with our international partners Dr. Parthiban Marimuthu from Åbo Akademi University (Finland) and Dr. Aamir Shahzad from Government College University Faisalabad (Pakistan), worked together to explore an important issue in neurodegenerative research. 🧠🧬
🧪 What’s it about?
This study reveals how oxidation affects the polymorphic structure of α-synuclein, a key protein involved in the progression of Parkinson’s disease. The findings provide molecular-level insights into how oxidative modifications influence fibril dynamics and may contribute to disease mechanisms.
🔬 A deeper understanding of these processes could pave the way for therapeutic strategies to prevent or reverse harmful α-synuclein aggregates in the brain. 🌟
Congratulations to everyone involved in this impactful study! 👏
https://www.frontiersin.org/journals/physics/articles/10.3389/fphy.2025.1591640/abstract
Ushbu tadqiqotda jamoamiz aʼzosi Dr. Tohir Akramov, magistrlar Muhriddin Maxkamov va Rasul Mashalov, shuningdek xalqaro hamkorlarimiz – Dr. Parthiban Marimuthu (Åbo Akademi Universiteti, Finlyandiya) va Dr. Aamir Shahzad (Pokiston, Faisalobod Davlat Universiteti) bilan birgalikda ish olib bordik. 🌍👨🔬
🔍 Nima oʻrganildi?
Ushbu tadqiqot Parkinson kasalligi bilan bogʻliq α-sinuklein oqsilining polimorf tuzilmasiga oksidlanish qanday ta’sir qilishini molekulyar darajada tahlil qildi.
🧬 Natijalar shuni ko‘rsatadiki, oksidlanish oqibatida ushbu oqsil tolalarining barqarorligi pasayadi, bu esa kasallik rivojlanishini oldini olishda muhim omil bo‘lishi mumkin.
🔬 Ushbu mexanizmlarni chuqur tushunish kelajakda davolash strategiyalarini ishlab chiqish uchun muhim asos bo‘lib xizmat qiladi.
🥳 Barcha hamkorlarga va ishtirokchilarga minnatdorchilik bildiraman – tabriklaymiz! 👏
[En] 📢 Our next research paper has been accepted for publication in Frontiers in Physics! 🎉📚
In this collaborative work, our team member Dr. Toxir Akramov, Master's students Mukhriddin Makhkamov and Mashalov Rasul, along with our international partners Dr. Parthiban Marimuthu from Åbo Akademi University (Finland) and Dr. Aamir Shahzad from Government College University Faisalabad (Pakistan), worked together to explore an important issue in neurodegenerative research. 🧠🧬
🧪 What’s it about?
This study reveals how oxidation affects the polymorphic structure of α-synuclein, a key protein involved in the progression of Parkinson’s disease. The findings provide molecular-level insights into how oxidative modifications influence fibril dynamics and may contribute to disease mechanisms.
🔬 A deeper understanding of these processes could pave the way for therapeutic strategies to prevent or reverse harmful α-synuclein aggregates in the brain. 🌟
Congratulations to everyone involved in this impactful study! 👏
https://www.frontiersin.org/journals/physics/articles/10.3389/fphy.2025.1591640/abstract
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The Life Scientific - Dame Pratibha Gai on training atoms to do what we want - BBC Sounds
https://www.bbc.co.uk/sounds/play/m002db9w
https://www.bbc.co.uk/sounds/play/m002db9w
BBC
The Life Scientific - Dame Pratibha Gai on training atoms to do what we want - BBC Sounds
Pratibha Gai on her microscope that brought chemical reactions into sharp focus.
Smart tiny 'seeds' grow carbon nanotubes to cool down small devices
https://interestingengineering.com/innovation/billion-tiny-seeds-grow-carbon-nanotubes
https://interestingengineering.com/innovation/billion-tiny-seeds-grow-carbon-nanotubes
Interesting Engineering
Smart tiny 'seeds' grow carbon nanotubes to cool down small devices
The goal is to understand and control the formation of alumina-supported iron nanoparticles using a high-tech microscope and machine learning.
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Scientists Confirm Anti-Aging Drug Appears to Prolong Life in Animals : ScienceAlert
https://www.sciencealert.com/scientists-confirm-anti-aging-drug-appears-to-prolong-life
https://www.sciencealert.com/scientists-confirm-anti-aging-drug-appears-to-prolong-life
ScienceAlert
Scientists Confirm Anti-Aging Drug Appears to Prolong Life in Animals
Encouraging early signs.
Google DeepMind Releases AlphaGenome: A Deep Learning Model that can more Comprehensively Predict the Impact of Single Variants or Mutations in DNA - MarkTechPost https://share.google/kIeFv6DaxByMt40JX
MarkTechPost
Google DeepMind Releases AlphaGenome: A Deep Learning Model that can more Comprehensively Predict the Impact of Single Variants…
Google DeepMind’s AlphaGenome predicts the functional impact of single DNA variants across modalities using deep learning
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Carbon Capture Reimagined: New Material Removes CO₂ From Air Like a Tree https://share.google/6cH7F14qJ43OY9yFQ
SciTechDaily
Carbon Capture Reimagined: New Material Removes CO₂ From Air Like a Tree
Scientists are designing a new living material that captures carbon dioxide directly from the air. It uses photosynthetic bacteria to trap CO₂ in both organic and mineral forms. The concept may sound futuristic: at ETH Zurich, researchers from multiple disciplines…
Navbatdagi hamkorlikdagi maqola!
🧪🧬 Qurbaqalar zahridan olingan tabiiy birikmalar SARS-CoV-2 virusiga qarshi samarali vosita!
Hamkorlikda olib borilgan ilmiy tadqiqotimiz Springer Nature nashriyotining Journal of Computer-Aided Molecular Design jurnalida chop etildi! 🎉
Tadqiqotni asosiy qismi Biorganik kimyo institutida faoliyat yuritayotgan Dr. Muzaffar Qayumov tomonidan amalga oshirildi.
Ushbu ilmiy izlanishlar doirasida O‘rta Osiyo yashil qurbaqasining (Bufo viridis) zahridan olingan olti xil bufalin (A–F) o‘rganildi. Molekulyar docking, molekulyar dinamika, erkin energiya hisoblashlari (umbrella sampling) va in vitro biokimyoviy testlar yordamida 3CLpro fermentiga qarshi kuchli ingibitorlik ko‘rsatgan birikmalar aniqlandi.
📊 Jumladan, bufalin (A) va gamabufotalin (C) IC₅₀ qiymatlari 1.37 µM va 2 µM bo‘lgan holda yuqori samaradorlik ko‘rsatdi. Bu birikmalar antivirus dori vositalari uchun kelajakdagi yetakchi nomzodlar sifatida baholandi.
🎉 Ushbu muvaffaqiyatli natija bilan barcha hammualliflarni tabriklaymiz va ilmiy hamkorlik uchun minnatdorchilik bildiramiz!
📄 Maqolaga havola: https://link.springer.com/article/10.1007/s10822-025-00623-2
🧪🧬 Qurbaqalar zahridan olingan tabiiy birikmalar SARS-CoV-2 virusiga qarshi samarali vosita!
Hamkorlikda olib borilgan ilmiy tadqiqotimiz Springer Nature nashriyotining Journal of Computer-Aided Molecular Design jurnalida chop etildi! 🎉
Tadqiqotni asosiy qismi Biorganik kimyo institutida faoliyat yuritayotgan Dr. Muzaffar Qayumov tomonidan amalga oshirildi.
Ushbu ilmiy izlanishlar doirasida O‘rta Osiyo yashil qurbaqasining (Bufo viridis) zahridan olingan olti xil bufalin (A–F) o‘rganildi. Molekulyar docking, molekulyar dinamika, erkin energiya hisoblashlari (umbrella sampling) va in vitro biokimyoviy testlar yordamida 3CLpro fermentiga qarshi kuchli ingibitorlik ko‘rsatgan birikmalar aniqlandi.
📊 Jumladan, bufalin (A) va gamabufotalin (C) IC₅₀ qiymatlari 1.37 µM va 2 µM bo‘lgan holda yuqori samaradorlik ko‘rsatdi. Bu birikmalar antivirus dori vositalari uchun kelajakdagi yetakchi nomzodlar sifatida baholandi.
🎉 Ushbu muvaffaqiyatli natija bilan barcha hammualliflarni tabriklaymiz va ilmiy hamkorlik uchun minnatdorchilik bildiramiz!
📄 Maqolaga havola: https://link.springer.com/article/10.1007/s10822-025-00623-2
SpringerLink
3CLpro of SARS-CoV-2 as a new target for bufadienolides: in silico and in vitro study
Journal of Computer-Aided Molecular Design - The rapid spread of SARS-CoV-2 and its widespread public health implications have highlighted the urgent need for effective antiviral therapies. A...
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Evapolectricity, produced for the first time in human history — It's the end of photovoltaics https://share.google/62AEOiRkXohqkQrsB
The Pulse
Evapolectricity, produced for the first time in human history — It's the end of photovoltaics
Mainstream and renewable electricity have their limitations; thankfully, there is a more viable solution. For the first time, evapolectricity has been produced.
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World’s most porous sponges: intricate carbon-trapping powders hit the market https://share.google/6YAu6sHHQTbWg54un
Nature
World’s most porous sponges: intricate carbon-trapping powders hit the market
Nature - Metal-organic frameworks were the next big thing in chemistry when they were invented more than three decades ago. Now, these intriguing materials are becoming commercial tools for...
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‘CrystalGPT’ set to enhance how chemists design crystals in silico | Research | Chemistry World https://share.google/3SEjIJVe3WwqPTeBE
Chemistry World
‘CrystalGPT’ set to enhance how chemists design crystals in silico
Model for predicting molecular crystal properties is readily adaptable to specific tasks, even with limited data
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As a new warning is released by scientists that trying to offset our carbon emissions by planting trees alone won’t work, we investigate the role the Earth’s forests are playing in the fight against climate change.
Marnie Chesterton is joined by Mark Maslin, Professor of Earth System Science at University College London, to help answer our top five questions about trees and CO2. - https://www.bbc.com/audio/play/m002dpns
Marnie Chesterton is joined by Mark Maslin, Professor of Earth System Science at University College London, to help answer our top five questions about trees and CO2. - https://www.bbc.com/audio/play/m002dpns
Bbc
BBC Audio | BBC Inside Science | Are trees the answer to solving climate change?
We investigate the role our forests are playing in offsetting carbon emissions.
🇺🇿 🎉 Institutimizda do‘stim, kursdoshim Shokir Pardaevni mehmon qildik! 👨🎓
Shokir Mississippi state universitetida magistratura, Kent state universitetida esa doktorlik darajasini olgan. 🧠 Hozirda u dunyodagi eng ilg‘or texnologik kompaniyalardan biri bo‘lgan Intel korporatsiyasida muhandis bo‘lib ishlamoqda. 💻🌍
Institutimizda olib borilayotgan tadqiqotlar bo‘yicha mazmunli suhbat qildik. Jumladan:
🔬 Plazma qishloq xo‘jaligi
🧬 Plazma yordamida saratonni davolash
💊 Sun’iy intellekt orqali dori ishlab chiqish
🌌 Astrofizika va kosmologiya
🌿 Bioo‘g‘itlar va GIS texnologiyalari
🌱 O‘simlik kasalliklarini aniqlashga mo‘ljallangan SI dasturlar
Shokir SI yordamida dori izlash mavzusiga katta qiziqish bildirdi va biz bu yo‘nalishda hamkorlikda loyiha boshlashga kelishib oldik. 🤝✨
Natijalarni tez orada baham ko‘ramiz! 📢
Institutimizga yana bir bor xush kelibsiz, Shokir! 🧪🌱🚀
🇺🇸 🚀 We were delighted to welcome my friend and former coursemate Dr. Shokir Pardaev to the Institute of Fundamental and Applied Research! 🎓
Shokir earned his Master’s degree from Mississippi State University and completed his PhD at Kent State University. 🧠 Currently, he works as an Engineer at Intel Corporation, one of the world’s leading tech companies. 💻🌍
During his visit, we had an inspiring discussion about the diverse research activities at our institute, including:
🔬 Plasma agriculture
🧬 Plasma-based cancer therapy
💊 AI-assisted drug discovery
🌌 Astrophysics and cosmology
🌿 Biofertilizers and GIS technologies
🧠 AI tools for plant disease detection
Shokir expressed strong interest in AI-driven drug discovery, and we are excited to announce our upcoming collaborative project in this area. 🤝✨
We look forward to sharing the results soon! 📢
Welcome again, Shokir! 🧪🌱🚀
Shokir Mississippi state universitetida magistratura, Kent state universitetida esa doktorlik darajasini olgan. 🧠 Hozirda u dunyodagi eng ilg‘or texnologik kompaniyalardan biri bo‘lgan Intel korporatsiyasida muhandis bo‘lib ishlamoqda. 💻🌍
Institutimizda olib borilayotgan tadqiqotlar bo‘yicha mazmunli suhbat qildik. Jumladan:
🔬 Plazma qishloq xo‘jaligi
🧬 Plazma yordamida saratonni davolash
💊 Sun’iy intellekt orqali dori ishlab chiqish
🌌 Astrofizika va kosmologiya
🌿 Bioo‘g‘itlar va GIS texnologiyalari
🌱 O‘simlik kasalliklarini aniqlashga mo‘ljallangan SI dasturlar
Shokir SI yordamida dori izlash mavzusiga katta qiziqish bildirdi va biz bu yo‘nalishda hamkorlikda loyiha boshlashga kelishib oldik. 🤝✨
Natijalarni tez orada baham ko‘ramiz! 📢
Institutimizga yana bir bor xush kelibsiz, Shokir! 🧪🌱🚀
🇺🇸 🚀 We were delighted to welcome my friend and former coursemate Dr. Shokir Pardaev to the Institute of Fundamental and Applied Research! 🎓
Shokir earned his Master’s degree from Mississippi State University and completed his PhD at Kent State University. 🧠 Currently, he works as an Engineer at Intel Corporation, one of the world’s leading tech companies. 💻🌍
During his visit, we had an inspiring discussion about the diverse research activities at our institute, including:
🔬 Plasma agriculture
🧬 Plasma-based cancer therapy
💊 AI-assisted drug discovery
🌌 Astrophysics and cosmology
🌿 Biofertilizers and GIS technologies
🧠 AI tools for plant disease detection
Shokir expressed strong interest in AI-driven drug discovery, and we are excited to announce our upcoming collaborative project in this area. 🤝✨
We look forward to sharing the results soon! 📢
Welcome again, Shokir! 🧪🌱🚀
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