[EN] Today, I had the opportunity to give a talk at the Institute of the Chemistry of Plant Substances on "The Power of Computer Simulations to Understand the Molecular Level Mechanisms that Occur at the Cellular Level" and it was amazing! I'm thrilled to have received such a positive response from the audience, including researchers expressing their interest and asking many questions. After the talk, we discussed possible future collaboration with the lab members of Azimova Shaxnoz Sadikovna, who have extracted various compounds and tested them for cell viability. Some of the compounds showed promising results against cancer cell lines, but we still have a lot of work to do to reveal the exact mechanisms behind this. Hopefully, our collaboration will be fruitful!
#Science #CancerResearch #Collaboration

🔬 Exciting News from Our Recent Paper! 🔬

📚 Title: In silico study of the impact of oxidation on pyruvate transmission across the hVDAC1 protein channel

Our recently published paper delves into the fascinating realm of cancer cell metabolism, focusing on the pivotal role of Voltage Dependent Anion Channels (VDACs), particularly VDAC1. Here's a snapshot of our findings:

🔍 Objective: Investigating the Effect of Low-Level VDAC1 Oxidation on Pyruvate Uptake

🧪 Methodology: Leveraging Molecular Dynamics (MD) Simulations

👉 Key Insights:
The overexpression of VDACs, especially VDAC1, in cancer cells compared to normal cells, has long been recognized. In our study, we honed in on the impact of a low level of VDAC1 oxidation, induced by Cold Atmospheric Plasma (CAP), on pyruvate (Pyr) uptake. Inhibiting Pyr uptake through VDAC1 emerges as a potential strategy to suppress cancer cell proliferation.

💡 Significant Findings:

Employed MD simulations to analyze hVDAC1 structure with modified cysteine and methionine residues.
Results indicated that the free energy barrier for Pyr translocation through the oxidized channel was significantly higher compared to the native channel.
Specifically, the barrier for Pyr translocation through the native channel was approximately 4.3 ± 0.7 kJ mol−1, while for the oxidized channel, it rose to 10.8 ± 1.8 kJ mol−1.
Higher barrier in the oxidized channel correlates with a decreased rate of Pyr permeation, suggesting a potential mechanism for inhibiting cancer cell proliferation.
🌐 Broader Implications:
Our findings unveil that low levels of CAP-induced oxidation reduce Pyr translocation, thereby curbing cancer cell proliferation. This suggests that subtle oxidative modifications may hold therapeutic potential in treating cancer cells by disrupting crucial metabolic pathways.

🚀 Future Directions:
Our research lays the groundwork for further exploration of CAP-induced oxidation as a targeted approach in cancer treatment. As we unravel the intricate connections between VDAC1, Pyr uptake, and cancer cell metabolism, we pave the way for innovative strategies in the fight against cancer.

🙌 Acknowledgments:
Kudos to our dedicated team for their commitment to advancing scientific knowledge and contributing to the ongoing discourse in cancer research. Together, we are shaping the future of cancer treatment!

#CancerResearch #ScienceBreakthrough #MolecularDynamics #ColdPlasma #InnovationInHealthcare #ResearchPublication

[UZ] 📚 Quvonarli yangilik! 🌟 2023-yil iyun oyida Pokistonlik hamkorimiz professor Aamir Shahzod tomonidan “Emerging Applications of Plasma Science in Allied Technologies” kitobiga bo‘lim yozish uchun taklif qilindim. 🚀 Kitob endi rasman nashr etildi va bizning "Saratonni davolashda termal bo'lmagan plazmani kompyuter simulyatsiyasi tadqiqotlari: kuchaytirilgan terapevtik samaradorlik uchun oqsil modifikatsiyalarini tushunish" bo'limimiz endi onlaynda mavjud!
👨‍🎓 Fidoyi shogirdim Davronjon Izzatulla Õğliga rahbarligimdagi mashaqqatli mehnati uchun alohida tashakkur va qimmatli hissasi uchun professor Zhitong Chenga chin dildan minnatdorchilik bildiraman.
🔍 Bizning bo'limning qisqacha mazmuni: Termal bo'lmagan plazma (NTP) hujayra signalizatsiyasiga ta'sir qilish va saraton hujayralarini tanlab nishonga olish orqali saraton kasalligini davolashda inqilob qilish arafasida. Bizning bo'lim NTP ning saratonni davolashda oqsillarga ta'siri bo'yicha so'nggi kompyuter simulyatsiyalari va tajribalarini o'rganib, uning salohiyatini optimallashtirish haqida tushuncha beradi. Saratonni shaxsiylashtirilgan davolash usullarining kelajagini shakllantiradigan molekulyar mexanizmlarni chuqur o'rganish uchun to'liq bobni o'qishingiz mumkin! https://www.igi-global.com/chapter/computer-simulation-studies-of-non-thermal-plasma-in-cancer-treatment/338042
📖 Qo'shimcha ma'lumot olish uchun ushbu havolaga o'ting: Bo'limni o'qing 🌐 #CancerResearch #BookCapter #InnovationInScience