Towards a large materials model for AI-driven materials discovery https://phys.org/news/2024-08-large-materials-ai-driven-discovery.html

[UZ] 🎉 O‘zbekiston Mustaqilligining 33 yilligi muborak bo‘lsin!
Mustaqillik millatning asosiy boyligi bo‘lib, u xalqning irodasi, orzu-umidlari va intilishlarini ifodalaydi. Bu bizga o‘z yo‘limizni belgilash, qadriyatlarimizni saqlab qolish va o‘zimizning boy tariximiz va madaniyatimizni aks ettiruvchi kelajakni qurish imkoniyatini beradi. O‘zbekiston mustaqilligining 33 yilligini nishonlar ekanmiz, bizni bu kunlarga yetaklagan kurash va fidoyilikni yodga olib, suverenitetimizni saqlash va mustahkamlashga bo‘lgan qat’iyatimizni yana bir bor tasdiqlaymiz.
Bugungi kunda dunyo bo‘ylab geosiyosiy ziddiyatlar kuchaymoqda va davlatlar oldida misli ko‘rilmagan sinovlar turibdi. Bunday qiyin sharoitda O‘zbekiston uchun rivojlanish va boshqa davlatlar, ayniqsa qo‘shni davlatlar bilan do‘stona munosabatlarni o‘rnatish juda muhimdir. 🤝 Diplomatiya va hamkorlik tinchlik va barqarorlikni ta’minlashning asosiy omillari bo‘lib, ular bizning o‘sish va ravnaqimizni qo‘llab-quvvatlaydi.
Yana-da kuchli bo‘lish uchun fan va texnologiyalarni rivojlantirish muhim ahamiyatga ega. O‘zbekiston olimlari birlashib, ulkan yutuqlarga erishishlari kerak. Bizning tadqiqotlarimiz bozorga yo‘naltirilgan mahsulotlarga olib kelishi va iqtisodiy mustaqilligimizga bevosita hissa qo‘shishi lozim. 📈 Jahon miqyosida raqobatlashish oson emas, va bu faqat olimlardan emas, balki barcha sohalardagi mutaxassislardan ham fidoyilikni talab qiladi. Har birimiz O‘zbekistonning rivojlangan davlatlar qatoriga kirishiga hissa qo‘shishimiz uchun maksimal darajada harakat qilishimiz zarur.
🎆 Yana bir bor Bayram Muborak Azizlarim! 🎆
[EN] 🎉 Happy 33rd Independence Day of Uzbekistan!
Independence is the cornerstone of a nation’s identity, representing the collective will, dreams, and aspirations of its people. It is a precious gift that allows us to determine our own path, uphold our values, and build a future that reflects our unique culture and history. As we celebrate 33 years of Uzbekistan's independence, we honor the struggles and sacrifices that have brought us to this moment and reaffirm our commitment to preserving and strengthening our sovereignty.
In today’s world, geopolitical tensions are rising, and nations face unprecedented challenges. In these difficult times, it is crucial for Uzbekistan to focus on its development and establish strong, friendly relations with other countries, especially our neighbors. 🤝 Diplomacy and cooperation are vital for ensuring peace and stability, which in turn supports our continued growth and prosperity.
To gain more strength, the development of science and technology is essential. The scientists of Uzbekistan must unite and strive for groundbreaking achievements. Our research should lead to market-ready products that directly contribute to our economic independence. 📈 Competing on the global stage is not easy, and it requires dedication not only from researchers but from professionals in all fields. Each of us must give our best to ensure that Uzbekistan is recognized as a developed nation.
🎆 I wish you a happy 33rd Independence Day! 🎆

Specialist 'carbon nanotube' AI chip built by Chinese scientists is 1st of its kind and '1,700 times more efficient' than Google's
https://www.yahoo.com/tech/specialist-carbon-nanotube-ai-chip-093020487.html

Delegation from IIT Roorkee Visits IFAR, Paves Way for Collaborative Research
Today, we were honored to host a delegation from the Indian Institute of Technology Roorkee 🇮🇳. Led by Rector Dr. K.K. Pant, the delegation included distinguished members: Prof. Naveen K. Navani (Dean of Academic Affairs), Prof. Summit Sen (Head of the Department of Hydrology), Dr. Vimal Chandra Srivastava (Dean of International Relations), and Dr. Ankit Agarwal (Assistant Professor, Department of Hydrology).
Our Head of Labs 🧪 also joined the meeting, where both parties agreed to establish a close partnership 🤝 on several cutting-edge projects. These include the development of bio-nanosensors for early cancer detection 🧬, research on antibacterial peptides 🦠, innovations in food preservation technology 🍎 to extend product shelf life, and applications of plasma technology ⚡️ in biosciences, particularly plasma agriculture 🌾 and wastewater treatment 💧. We also explored the use of artificial intelligence in agriculture 🤖. The discussions were highly constructive, and we are optimistic that this visit will pave the way for mutually beneficial collaborations 🤝.
Following this, the delegation engaged in further discussions with our rector, Prof. Bakhadir Mirzaev, during which both sides outlined their research potential and opportunities for academic and student exchanges 🧑‍🎓. The meeting culminated in the signing of a Memorandum of Understanding (MoU) 📜 between the rectors, formalizing our commitment to collaboration.
We sincerely thank the IIT Roorkee delegation 🙏 for visiting IFAR, and we look forward to the fruitful outcomes of this partnership.

12 PhD Degree-Fully Funded at Lund University, Scania, Sweden - Vacancy Edu
https://vacancyedu.com/12-phd-degree-fully-funded-at-lund-university-scania-sweden-2/

[UZ] 🌟 Ilmiy tadqiqotlarimizdan ajoyib yangilik! 🌟
Alzheimer kasalligi (AD) bo‘yicha yangi tadqiqotimiz, dunyo bo‘ylab millionlab insonlarga ta'sir qiluvchi og‘ir nevrodejenerativ kasallik, Nature nashryotining Scientific Reports jurnalida chop etildi. 🧠✨
Ushbu tadqiqotda biz statik va o’zgaruvchan elektr maydonlari Alzheimer kasalligi bilan bog‘liq bo‘lgan zararli Aβ fibrillarini qanday buzishini o‘rgandik. Molekulyar dinamika simulyatsiyalari yordamida, toksikligi va barqaror tuzilishi bilan mashhur bo‘lgan Osaka mutatsiyasi (E22Δ) ga ega Aβ1–40 peptidining polimorfik fibril kompleksini tadqiq qildik.
Tadqiqot natijalarimiz shuni ko‘rsatadiki, 0.3–0.4 V/nm elektr maydoni va 0.20 GHz chastota bilan bu zararli fibrillarni samarali ravishda buzish mumkin. Bu yondashuv Alzheimer kasalligini davolash bo‘yicha yangi terapevtik usullarni ochib berishi mumkin. 🔬⚡️
Ushbu tadqiqotda ko‘rsatgan qimmatli hissalari uchun Dr. Artyom Baev (Ilg’or texnologiyalar markazi), Dr. Erkin S Kurganov (Broad Institute of MIT and Harvard), va fidoyi magistr talabam Muhriddin Mahkamovga katta rahmat aytaman.
To‘liq maqolani bu yerda o‘qing: https://www.nature.com/articles/s41598-024-72778-1
(Mana nima uchun mahalliy va xalqaro hamkorlik kerak!!!)
[EN] 🌟 Exciting Research Update! 🌟
Our latest study on Alzheimer’s disease (AD), a devastating neurodegenerative disorder affecting millions worldwide, has been published in Nature’s Scientific Reports. 🧠✨
In this research, we explored how static and oscillating electric fields can disrupt the harmful Aβ fibrils associated with AD. Using molecular dynamics simulations, we specifically examined a polymorphic fibrillar complex of the Aβ1–40 peptide with the Osaka mutation (E22Δ), which is known for its toxicity and stable structure.
Our findings reveal that applying a 0.3–0.4 V/nm electric field at a 0.20 GHz frequency can effectively disrupt these toxic fibrils, potentially offering a novel therapeutic approach to combating AD pathology. This is a promising step forward in understanding and addressing Alzheimer’s disease. 🔬⚡️
A huge thank you to Dr. Artyom Baev, Dr. Erkin Kurganov, and my dedicated student Mukhriddin Makhkamov for their valuable contributions to this work.
#AlzheimersResearch #NeurodegenerativeDisorders #MolecularDynamics #Therapeutics #ScientificReports #ElectricFields #ResearchInnovation #ADPathology

Chemists use light to replace an oxygen atom with a nitrogen atom in a molecule
https://phys.org/news/2024-10-chemists-oxygen-atom-nitrogen-molecule.html

Jamoamizga yaqinda qo'shilgan Dr. Maksudbek Yusupovni Redox Biology (IF-10.7) jurnalida chop etgan maqolasi bilan chin dildan tabriklaymiz! 🎉 https://www.sciencedirect.com/science/article/pii/S2213231724003598?via%3Dihub

How Cells Outsmart Starvation: Scientists Discover Intriguing New Mechanism
https://scitechdaily.com/how-cells-outsmart-starvation-scientists-discover-intriguing-new-mechanism/

🚀 Collaboration and Publication! 🚀
In March, my colleague, Prof. Pankaj Attri (Kyushu University - Japan), reached out to me, mentioning that his friend, Prof. Reddy (Yogi Vemana University - India), needed molecular simulation results for an ongoing experimental project. They were testing anti-cancer drugs in vitro, which effectively inhibited the proliferation of cancer cells.
After discussing the details and explaining how we would conduct the molecular modeling, Prof. Reddy agreed to collaborate with us. I tasked my Master's student, Mukhriddin Makhkamov, with exploring the binding poses of these drugs with the tubulin protein. Our modeling results qualitatively complemented the experimental findings, unveiling the mechanism at the molecular level. 💻🔬
We integrated these insights, and I’m excited to share that our article has been published in the Journal of Molecular Structure (IF-4.0). 🎉
I am a strong advocate for scientific collaboration, and I always encourage my students to engage in both local and international partnerships. Through cooperation, we can achieve so much more in advancing science. 🌍🤝
🔗 More about our article: https://www.sciencedirect.com/science/article/abs/pii/S0022286024028643?via%3Dihub

What are proteins again? Nobel-winning chemistry explained
https://phys.org/news/2024-10-proteins-nobel-chemistry.html

Catalyst Magic: Game-Changing Method for Alkane Activation Discovered in Japan
https://scitechdaily.com/catalyst-magic-game-changing-method-for-alkane-activation-discovered-in-japan/