Computer_simulations_Uz
543 subscribers
468 photos
81 videos
89 files
400 links
Ushbu kanal talabalarda kompyuterda modellashtirish ko’nikmalarini hosil qilish va kelajakda sohada yetuk kadrlar tayyorlashni maqsad qilgan.
Download Telegram
Delegation from IIT Roorkee Visits IFAR, Paves Way for Collaborative Research
Today, we were honored to host a delegation from the Indian Institute of Technology Roorkee 🇮🇳. Led by Rector Dr. K.K. Pant, the delegation included distinguished members: Prof. Naveen K. Navani (Dean of Academic Affairs), Prof. Summit Sen (Head of the Department of Hydrology), Dr. Vimal Chandra Srivastava (Dean of International Relations), and Dr. Ankit Agarwal (Assistant Professor, Department of Hydrology).
Our Head of Labs 🧪 also joined the meeting, where both parties agreed to establish a close partnership 🤝 on several cutting-edge projects. These include the development of bio-nanosensors for early cancer detection 🧬, research on antibacterial peptides 🦠, innovations in food preservation technology 🍎 to extend product shelf life, and applications of plasma technology ⚡️ in biosciences, particularly plasma agriculture 🌾 and wastewater treatment 💧. We also explored the use of artificial intelligence in agriculture 🤖. The discussions were highly constructive, and we are optimistic that this visit will pave the way for mutually beneficial collaborations 🤝.
Following this, the delegation engaged in further discussions with our rector, Prof. Bakhadir Mirzaev, during which both sides outlined their research potential and opportunities for academic and student exchanges 🧑‍🎓. The meeting culminated in the signing of a Memorandum of Understanding (MoU) 📜 between the rectors, formalizing our commitment to collaboration.
We sincerely thank the IIT Roorkee delegation 🙏 for visiting IFAR, and we look forward to the fruitful outcomes of this partnership.
👏4
[UZ] 🌟 Ilmiy tadqiqotlarimizdan ajoyib yangilik! 🌟
Alzheimer kasalligi (AD) bo‘yicha yangi tadqiqotimiz, dunyo bo‘ylab millionlab insonlarga ta'sir qiluvchi og‘ir nevrodejenerativ kasallik, Nature nashryotining Scientific Reports jurnalida chop etildi. 🧠
Ushbu tadqiqotda biz statik va o’zgaruvchan elektr maydonlari Alzheimer kasalligi bilan bog‘liq bo‘lgan zararli Aβ fibrillarini qanday buzishini o‘rgandik. Molekulyar dinamika simulyatsiyalari yordamida, toksikligi va barqaror tuzilishi bilan mashhur bo‘lgan Osaka mutatsiyasi (E22Δ) ga ega Aβ1–40 peptidining polimorfik fibril kompleksini tadqiq qildik.
Tadqiqot natijalarimiz shuni ko‘rsatadiki, 0.3–0.4 V/nm elektr maydoni va 0.20 GHz chastota bilan bu zararli fibrillarni samarali ravishda buzish mumkin. Bu yondashuv Alzheimer kasalligini davolash bo‘yicha yangi terapevtik usullarni ochib berishi mumkin. 🔬⚡️
Ushbu tadqiqotda ko‘rsatgan qimmatli hissalari uchun Dr. Artyom Baev (Ilg’or texnologiyalar markazi), Dr. Erkin S Kurganov (Broad Institute of MIT and Harvard), va fidoyi magistr talabam Muhriddin Mahkamovga katta rahmat aytaman.
To‘liq maqolani bu yerda o‘qing: https://www.nature.com/articles/s41598-024-72778-1
(Mana nima uchun mahalliy va xalqaro hamkorlik kerak!!!)
[EN] 🌟 Exciting Research Update! 🌟
Our latest study on Alzheimer’s disease (AD), a devastating neurodegenerative disorder affecting millions worldwide, has been published in Nature’s Scientific Reports. 🧠
In this research, we explored how static and oscillating electric fields can disrupt the harmful Aβ fibrils associated with AD. Using molecular dynamics simulations, we specifically examined a polymorphic fibrillar complex of the Aβ1–40 peptide with the Osaka mutation (E22Δ), which is known for its toxicity and stable structure.
Our findings reveal that applying a 0.3–0.4 V/nm electric field at a 0.20 GHz frequency can effectively disrupt these toxic fibrils, potentially offering a novel therapeutic approach to combating AD pathology. This is a promising step forward in understanding and addressing Alzheimer’s disease. 🔬⚡️
A huge thank you to Dr. Artyom Baev, Dr. Erkin Kurganov, and my dedicated student Mukhriddin Makhkamov for their valuable contributions to this work.
#AlzheimersResearch #NeurodegenerativeDisorders #MolecularDynamics #Therapeutics #ScientificReports #ElectricFields #ResearchInnovation #ADPathology
👍17👏2🔥1
Jamoamizga yaqinda qo'shilgan Dr. Maksudbek Yusupovni Redox Biology (IF-10.7) jurnalida chop etgan maqolasi bilan chin dildan tabriklaymiz! 🎉 https://www.sciencedirect.com/science/article/pii/S2213231724003598?via%3Dihub
👍12🔥5👏4
🚀 Collaboration and Publication! 🚀
In March, my colleague, Prof. Pankaj Attri (Kyushu University - Japan), reached out to me, mentioning that his friend, Prof. Reddy (Yogi Vemana University - India), needed molecular simulation results for an ongoing experimental project. They were testing anti-cancer drugs in vitro, which effectively inhibited the proliferation of cancer cells.
After discussing the details and explaining how we would conduct the molecular modeling, Prof. Reddy agreed to collaborate with us. I tasked my Master's student, Mukhriddin Makhkamov, with exploring the binding poses of these drugs with the tubulin protein. Our modeling results qualitatively complemented the experimental findings, unveiling the mechanism at the molecular level. 💻🔬
We integrated these insights, and I’m excited to share that our article has been published in the Journal of Molecular Structure (IF-4.0). 🎉
I am a strong advocate for scientific collaboration, and I always encourage my students to engage in both local and international partnerships. Through cooperation, we can achieve so much more in advancing science. 🌍🤝
🔗 More about our article: https://www.sciencedirect.com/science/article/abs/pii/S0022286024028643?via%3Dihub
🔥8👍4👏1