[UZ] 📢 Navbatdagi maqolamiz Nature nashryotining Scientific Reports jurnalida chop etildi! 🎉
Saraton hujayralaridagi PD-L1 va PD-L2 immun nazorat oqsillari immun hujayralari faolligini boshqarishda muhim rol o‘ynaydi va immun retseptori PD1 oqsili bilan bog'lanishi saraton hujayralari tomonidan “himoya mexanizmi (don't eat me signal)” sifatida ishlatiladi. Tadqiqotimizda sovuq atmosferik plazma (SAP) tomonidan oksidlanish oqsillarni bog'lanishiga qanday ta’sir ko‘rsatishini molekulyar dinamika (MD) simulyatsiyalari yordamida o‘rgandik. Natijalarimiz SAP ta’sirida oksidlanish kuchayishi PD-1 va uning ligandlari (PD-L1/PD-L2) o‘rtasidagi bog‘lanishni zaiflashtirishini ko‘rsatdi. Bu esa saratonga qarshi immunitet hujayralarini faolligini kuchaytirishda yangi strategiya sifatida foydalanish mumkin.
Ushbu tadqiqotni iste’dodli magistrantlarim: Rasulbek Mashalov (Debretsen Universiteti) va Zulfizar Toshpulatova (O‘zbekiston Milliy Universiteti, Kimyo fakulteti) tomonidan amalga oshirilgan. 🙌 Shogirdlarimning muvaffaqiyatini ko‘rish men uchun beqiyos quvonch va faxrdir. 🌟
[EN] 📢 Our latest paper has been published in Scientific Reports, a journal from the Nature Publishing Group! 🎉
The immune checkpoint proteins PD-L1 and PD-L2 play a crucial role in regulating the activity of immune cells, and their binding with PD-1 is often exploited by cancer cells as a “don’t eat me” signal. In our study, we used molecular dynamics (MD) simulations to investigate how cold atmospheric plasma (CAP)-induced oxidation affects these protein interactions. Our findings show that increasing oxidation levels caused by CAP weaken the binding between PD-1 and its ligands (PD-L1/PD-L2). This suggests a promising new strategy to enhance the activity of immune cells against cancer.
This research was carried out thanks to the remarkable efforts of my talented Master’s students: Rasul Mashalov (University of Debrecen) and Zulfizar Toshpulatova (National University of Uzbekistan, Faculty of Chemistry). 🙌 Seeing the success of my students brings me immense joy and pride. 🌟 https://www.nature.com/articles/s41598-025-12902-x#additional-information
Saraton hujayralaridagi PD-L1 va PD-L2 immun nazorat oqsillari immun hujayralari faolligini boshqarishda muhim rol o‘ynaydi va immun retseptori PD1 oqsili bilan bog'lanishi saraton hujayralari tomonidan “himoya mexanizmi (don't eat me signal)” sifatida ishlatiladi. Tadqiqotimizda sovuq atmosferik plazma (SAP) tomonidan oksidlanish oqsillarni bog'lanishiga qanday ta’sir ko‘rsatishini molekulyar dinamika (MD) simulyatsiyalari yordamida o‘rgandik. Natijalarimiz SAP ta’sirida oksidlanish kuchayishi PD-1 va uning ligandlari (PD-L1/PD-L2) o‘rtasidagi bog‘lanishni zaiflashtirishini ko‘rsatdi. Bu esa saratonga qarshi immunitet hujayralarini faolligini kuchaytirishda yangi strategiya sifatida foydalanish mumkin.
Ushbu tadqiqotni iste’dodli magistrantlarim: Rasulbek Mashalov (Debretsen Universiteti) va Zulfizar Toshpulatova (O‘zbekiston Milliy Universiteti, Kimyo fakulteti) tomonidan amalga oshirilgan. 🙌 Shogirdlarimning muvaffaqiyatini ko‘rish men uchun beqiyos quvonch va faxrdir. 🌟
[EN] 📢 Our latest paper has been published in Scientific Reports, a journal from the Nature Publishing Group! 🎉
The immune checkpoint proteins PD-L1 and PD-L2 play a crucial role in regulating the activity of immune cells, and their binding with PD-1 is often exploited by cancer cells as a “don’t eat me” signal. In our study, we used molecular dynamics (MD) simulations to investigate how cold atmospheric plasma (CAP)-induced oxidation affects these protein interactions. Our findings show that increasing oxidation levels caused by CAP weaken the binding between PD-1 and its ligands (PD-L1/PD-L2). This suggests a promising new strategy to enhance the activity of immune cells against cancer.
This research was carried out thanks to the remarkable efforts of my talented Master’s students: Rasul Mashalov (University of Debrecen) and Zulfizar Toshpulatova (National University of Uzbekistan, Faculty of Chemistry). 🙌 Seeing the success of my students brings me immense joy and pride. 🌟 https://www.nature.com/articles/s41598-025-12902-x#additional-information
Nature
Molecular dynamics insights into the redox effects on PD-1/PD-L1 and PD-1/PD-L2 interactions
Scientific Reports - Molecular dynamics insights into the redox effects on PD-1/PD-L1 and PD-1/PD-L2 interactions
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