"Here we assemble an interactive open resource to benchmark brain morphology derived from any current or future sample of MRI data (https://www.brainchart.io/). With the goal of basing these reference charts on the largest and most inclusive dataset available, acknowledging limitations due to known biases of MRI studies relative to the diversity of the global population, we aggregated 123,984 MRI scans, across more than 100 primary studies, from 101,457 human participants between 115 days post-conception to 100 years of age. MRI metrics were quantified by centile scores, relative to non-linear trajectories of brain structural changes, and rates of change, over the lifespan. Brain charts identified previously unreported neurodevelopmental milestones, showed high stability of individuals across longitudinal assessments, and demonstrated robustness to technical and methodological differences between primary studies."

Bethlehem, R.A.I., Seidlitz, J., White, S.R. ... Alexander-Bloch, A.F. Brain charts for the human lifespan. Nature (2022). Published: 06 April 2022. https://doi.org/10.1038/s41586-022-04554-y [ Open Access ]

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