Bacteria Can ‘Outsmart’ Programmed Cell Death Overriding an Immune System Defense Mechanism

کشف چگونگی کنترل سیستم ایمنی در عفونت با باکتری شیگلا...
نتیجه این پژوهش بسیار ارزشمند توسط ایمونولوژیست ایرانی مقیم کلن آلمان، در آخرین شماره Nature Immunology به چاپ رسیده است

@Immunology_board

متن کامل مقاله را در لینک زیر بخوانید

Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide


@Immunology_board
@Lab_science

Coming soon...

#Immuno_TACT
#iTACT
#USERN


متن خلاصه شده را در سایت خبری زیر بخوانید

https://scitechdaily.com/bacteria-can-outsmart-programmed-cell-death-overriding-an-immune-system-defense-mechanism/

Finding a new way to fight late-stage sepsis by boosting cells' antibacterial properties
تحولی در تقویت سیستم ایمنی در پاسخ به عفونت سیستمیک

Immunology scientists have developed a way to prop up a struggling immune system to enable its fight against sepsis, a deadly condition resulting from the body's extreme reaction to infection.

@Immunology_board

Coming soon:

#Immuno_TACT
#iTACT

This work combined two primary types of technology: using vitamins as the main component in making lipid nanoparticles, and using those nanoparticles to capitalize on natural cell processes in the creation of a new antibacterial drug.

در این تحقیق که از تلفیق نانو تکنولوژی و روند های طبیعی پروسسینگ سلولی استفاده شده در تقویت ماکروفاژها برای پاسخ ایمنی در عفونت به کار گرفته شده.

Cells called macrophages are one of the first responders in the immune system, with the job of "eating" invading pathogens. However, in patients with sepsis, the number of macrophages and other immune cells are lower than normal and they don't function as they should.

مقاله کامل را در لینک ژورنال نیچر نانو بیوتکنولوژی مطالعه کنید
Read the full story in Nature Nanobiotechnology (link)

@Immunology_board
@Lab_science

Coming soon:

#Immuno_TACT
#iTACT
#USERN


https://phys.org/news/2020-01-late-stage-sepsis-boosting-cells-antibacterial.html

متن کامل مقاله مربوط به خبر بالا 👆

Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis

Nature Nanobiotechnology

@Immunology_board
@Lab_science

#Immuno_TACT
#iTACT
@USERN_net
#USERN

Immunology Board for Transplantation and Cell-based Therapeutics (Immuno-TACT)

Stay tuned for...
#Immuno_TACT
#iTACT
#USERN
@Immunology_board
@USERN_net

@Immunology_board
@Lab_science
@DrAkbarpourM

Immunology Board For Transplantation And Cell-Based Therapeutics (Immuno_TACT)

Register to #USERN and join our interest group Immuno_TACT

👇More information about Immuno_TACT

https://usern.tums.ac.ir/Group/Info/Immuno_TACT

#Immuno_TACT
@USERN_net

Discovery of the human major histocompatibility complex (MHC) in the late ’60s made remarkable development in the field of organ and tissue transplantation. Graft acceptance significantly increased by matching of donor and recipient for MHC antigens and with our better understanding of the immune system engagement in the tolerance or rejection of the graft and graft vs host disease. Advances in the field of transplantation immunology have allowed the exponential growth of solid organ transplantations, bone marrow and stem cell transplantation for primary immunodeficiencies, hematologic malignancies, solid tumor, as well as autoimmune diseases. Future developments in the field of transplantation immunology will not only advance our knowledge on a better understanding of the immune system components on the immunobiology of transplantation but also provide appropriate immunological TACTs to minimize graft rejection and development of novel immune cell therapies such as CAR T-cells while supplement overall immunity to provide longer survival for patients.

@Immunology_board
#Immuno_TACT
#iTACT
@USERN_net
@Lab_science

Immuno-TACT will provide opportunities for scientists and young fellows to collaborate by learning and building on their collective strengths, expanding their knowledge of cutting-edge techniques, and growing their professional networks. Seek out and facilitate innovative research opportunities for members Nurture and develop tomorrow's transplant leaders through dynamic relationships with industry and academic institutions Create innovative ways to train investigators in the latest technologies for scientific research Tele-Conferences, podcasts, and talk series on selected topics in Immuno-TACT (iTACT) Universal networking of Immuno-TACT strategic mission through scientific publications, multimedia development, and web-based advanced communication networks.

[email protected]

@Immunology_board
#Immuno_TACT
#iTACT
@USERN_net
@Lab_science

4 Strategies For Success In The CAR-T 2.0 Marketplace

As this second wave of CAR-T therapies begins coming to market in the next five years, their manufacturers will need to anticipate and prepare to address many of the same commercial challenges as their predecessors, as well as several additional ones, including:

@Immunology_board
@Lab_science

1- Effective Physician Education
2- Logistical Excellence
3- Market Access Excellence
4- Demonstrate Clear Value Through Evidence Generation

Read the full story here:
https://www.cellandgene.com/doc/strategies-for-success-in-the-car-t-marketplace-0001

#Immuno_TACT
#iTACT
#CellTherapy
#Immunotherapy
#ImmuneCellTherapy
#CARTcell



@Immunology_board
@Lab_science