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‼️Just published Round #2 of in-depth analysis of the UK ONS all-cause data by vaccination status for England!
Read my Substack for free here: https://usmortality.substack.com/p/round-2-of-ons-all-cause-mortality
Read my Substack for free here: https://usmortality.substack.com/p/round-2-of-ons-all-cause-mortality
All-Cause Mortality Monitoring - USMortality.com
Round #2 of ONS All-Cause Mortality Data Analysis
Today, I have analyzed the UK ONS All-Cause Mortality data for England in two additional dimensions. If you haven’t read my first article, please check it out here. First I looked at all-cause mortality by vaccination status & sex, and secondly by age group…
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This is how UK's statistics office (ONS) calculates vaccine efficacy!
Unbelievable. #FakeScience
@USMortality
Unbelievable. #FakeScience
@USMortality
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PSA: There have been many spammers/scammers using my name to reach out to followers of this channel. Please be aware. I will never send any direct messages to you. Especially asking for money or any other contributions, offers or solicitations.
Please stay safe!
Please stay safe!
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In my latest article: "SARS-CoV-2 Genome Assembly (Part 2)" I follow up on the result of my article from six months ago, and why I think my findings from back then, are still valid today.
https://usmortality.substack.com/p/sars-cov-2-genome-assembly-part-2
https://usmortality.substack.com/p/sars-cov-2-genome-assembly-part-2
USMortality
SARS-CoV-2 Genome Assembly (Part 2)
An update to my post from six months ago.
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🔥 How Accurate is the COVID-19 PCR Test Really? 🦠
Wu et al. 2020 published three versions of the SARS-CoV-2 genome sequence. It is assumed, that based on these sequences, Christian Drosten designed the first PCR protocol for COVID-19.
— A deep dive into Christian Drosten's COVID-19 PCR Primers... —
> Eight of ten SARS-CoV-2 PCR primers (Corman-Drosten et al 2020) are found in the SARS-CoV-2 genome.
> All primers, by themselves, show at least a two third match to the human genome.
> The primer “N_Sarbeco_R” shows a match of 19/20 base pairs to the human genome.
> The real world impact of these results remain unclear, but many open questions arise!
Whole story for free on my substack:
https://usmortality.substack.com/p/how-accurate-is-the-covid-19-pcr
@USMortality
Wu et al. 2020 published three versions of the SARS-CoV-2 genome sequence. It is assumed, that based on these sequences, Christian Drosten designed the first PCR protocol for COVID-19.
— A deep dive into Christian Drosten's COVID-19 PCR Primers... —
> Eight of ten SARS-CoV-2 PCR primers (Corman-Drosten et al 2020) are found in the SARS-CoV-2 genome.
> All primers, by themselves, show at least a two third match to the human genome.
> The primer “N_Sarbeco_R” shows a match of 19/20 base pairs to the human genome.
> The real world impact of these results remain unclear, but many open questions arise!
Whole story for free on my substack:
https://usmortality.substack.com/p/how-accurate-is-the-covid-19-pcr
@USMortality
MortalityWatch (USMortality)
How Accurate is the COVID-19 PCR Test Really?
A deep dive into Christian Drosten's COVID-19 PCR Primers...
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🔥US President Biden finally ends the COVID-19 emergency!
Long overdue - as it should have been ended in June 2020 - after it was clear that this is essentially the flu.
https://www.whitehouse.gov/briefing-room/legislation/2023/04/10/bill-signed-h-j-res-7/
Free Full Article: https://blog.usmortality.com/p/us-ends-covid-19-emergency
@USMortality
Long overdue - as it should have been ended in June 2020 - after it was clear that this is essentially the flu.
https://www.whitehouse.gov/briefing-room/legislation/2023/04/10/bill-signed-h-j-res-7/
Free Full Article: https://blog.usmortality.com/p/us-ends-covid-19-emergency
@USMortality
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🔥 BIG UPDATE 🔥 to Mortality.Watch is now live!
Major Changes:
> Complete rewrite in @vuejs - hence overall better usability and maintainability.
> Light & Dark Theme Support
> Excess Mortality as Percentage
➡️ https://www.mortality.watch
Feel free to support by subscribing to my Twitter (twitter.com/usmortality) or Substack (blog.usmortality.com)!
Major Changes:
> Complete rewrite in @vuejs - hence overall better usability and maintainability.
> Light & Dark Theme Support
> Excess Mortality as Percentage
➡️ https://www.mortality.watch
Feel free to support by subscribing to my Twitter (twitter.com/usmortality) or Substack (blog.usmortality.com)!
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BREAKING: US ends COVID-19 Unvaccinated Travel Ban! The White House just announced, that they will end the unscientific and inhumane travel ban on May 11, 2023!
@USMortality
https://usmortality.substack.com/p/breaking-us-ends-covid-19-unvaccinated
@USMortality
https://usmortality.substack.com/p/breaking-us-ends-covid-19-unvaccinated
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🔥 NEW updates today for mortality.watch
➡️ Add new Mid-year (July 1- June 30) time frame
➡️ Add different ASMR standard tables (WHO2015, ESP2013, US2000, Country2020)
➡️ Unified Country list, that shows data availability inline (Deaths | CMR, ASMR)
➡️ Fixed a bug where incomplete aggregate ASMR data was shown.
🙏 If you like my work, please consider subscribing to my Twitter or Substack. Thanks!
💡If you have ideas or feature requests, please vote and submit them here: https://mortalitywatch.canny.io/feature-requests
➡️ Add new Mid-year (July 1- June 30) time frame
➡️ Add different ASMR standard tables (WHO2015, ESP2013, US2000, Country2020)
➡️ Unified Country list, that shows data availability inline (Deaths | CMR, ASMR)
➡️ Fixed a bug where incomplete aggregate ASMR data was shown.
🙏 If you like my work, please consider subscribing to my Twitter or Substack. Thanks!
💡If you have ideas or feature requests, please vote and submit them here: https://mortalitywatch.canny.io/feature-requests
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🧬 Is the SARS-CoV-2 Genome Valid?
A closer look at the first genetic reads mapping.
Aligning the original reads that are published by Wu et al. 2020 to the SARS-CoV-2 reference genome yields a coverage of 99.993%. However, a closer look at the alignments, specifically for the head & tail of the novel genome, reveals that none of the original reads match sufficiently enough to establish certainty about the validity of the reference genome.
While the theoretical assembly via De Bruijn graph algorithm appears to be valid - for a novel genome, the edges should be specifically important. One might certainly expect, to find reads, that perfectly map to the head (and tail) of the genome - imagine it similar to an edge piece of a puzzle!
Hence, if we look at the individual reads, I would expect to find many reads, that align perfectly to the edges of the reference genome (MN908947.3).
But that's not the case!
At the minimum it should be shown, that:
1) At least 10–20 reads that show a perfect alignment to the head & the tail.
2) A complete genetic sequence (RNA) of ~30kb length exists in the sample.
To my knowledge, neither of these two conditions have been fulfilled, to this date.
I could not find any compelling evidence, that the SARS-CoV-2 reference genome is valid, specifically when looking at the head & tail alignments.
Read the full article for free:
https://usmortality.substack.com/p/is-the-sars-cov-2-genome-valid?utm_source=telegram&sd=pf
A closer look at the first genetic reads mapping.
Aligning the original reads that are published by Wu et al. 2020 to the SARS-CoV-2 reference genome yields a coverage of 99.993%. However, a closer look at the alignments, specifically for the head & tail of the novel genome, reveals that none of the original reads match sufficiently enough to establish certainty about the validity of the reference genome.
While the theoretical assembly via De Bruijn graph algorithm appears to be valid - for a novel genome, the edges should be specifically important. One might certainly expect, to find reads, that perfectly map to the head (and tail) of the genome - imagine it similar to an edge piece of a puzzle!
Hence, if we look at the individual reads, I would expect to find many reads, that align perfectly to the edges of the reference genome (MN908947.3).
But that's not the case!
At the minimum it should be shown, that:
1) At least 10–20 reads that show a perfect alignment to the head & the tail.
2) A complete genetic sequence (RNA) of ~30kb length exists in the sample.
To my knowledge, neither of these two conditions have been fulfilled, to this date.
I could not find any compelling evidence, that the SARS-CoV-2 reference genome is valid, specifically when looking at the head & tail alignments.
Read the full article for free:
https://usmortality.substack.com/p/is-the-sars-cov-2-genome-valid?utm_source=telegram&sd=pf
MortalityWatch (USMortality)
Is the SARS-CoV-2 Genome Valid?
A closer look at the first genetic reads mapping.
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Why the Ends of the Genome are Important
Discovering what we can learn from simulating shotgun sequencing
Summary: We can see that using 100 reference genomes, and an error rate of 1%, we end up with about ~15 perfectly aligned reads against the head and the tail (and a general coverage of 24). This means if an entire genome was present in the sample, we should be able to find reads that perfectly align against that novel genome.
Megahit did assemble the head and the ‘body’ of the genome entirely, but struggled with the (polyA)-tail. This could be due to the average read length of 100bp, but the tail just has 34x A's, so it remains unclear why Megahit is not able to entirely assemble the genome.
Channel: @USMortality
Full article: https://usmortality.substack.com/p/why-the-ends
Discovering what we can learn from simulating shotgun sequencing
Summary: We can see that using 100 reference genomes, and an error rate of 1%, we end up with about ~15 perfectly aligned reads against the head and the tail (and a general coverage of 24). This means if an entire genome was present in the sample, we should be able to find reads that perfectly align against that novel genome.
Megahit did assemble the head and the ‘body’ of the genome entirely, but struggled with the (polyA)-tail. This could be due to the average read length of 100bp, but the tail just has 34x A's, so it remains unclear why Megahit is not able to entirely assemble the genome.
Channel: @USMortality
Full article: https://usmortality.substack.com/p/why-the-ends
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How Reliable is Megahit?
A Quality Control Study of the Tools Used to Discover the SARS-CoV-2 Genome
Methodology
I have downloaded reference genomes of 20 common viruses, including SARS1/2, Ebola, Influenza and Measles. In a first step, we’ll run each genome through the step of random fragmentation into ~100bp long reads (min: 50bp; max: 150bp), generated via my genome.ts script and Sanger institute’s wgsim tool. Then we will use these reads to align them against the reference genome, and in a second step use Megahit to assemble the reads and compare the produced assembly (contigs) to the reference genome.
Summary
Read alignment appears to be accurate. However, as alignment has to be carried out against a reference genome, which is typically identified at first via de-novo assembly, the reliability of the assembly step should be even more important. Here, the de-novo assembly with Megahit - which was used to discover the SARS-CoV-2 genome - shows insufficient reliability in reconstructing entire genomes, as it has failed to reconstruct between 4-7 of the 20 tested reference genomes, including SARS-CoV(-1) and SARS-CoV-2.
@USMortality
Full article: https://usmortality.substack.com/p/how-reliable-is-megahit
A Quality Control Study of the Tools Used to Discover the SARS-CoV-2 Genome
Methodology
I have downloaded reference genomes of 20 common viruses, including SARS1/2, Ebola, Influenza and Measles. In a first step, we’ll run each genome through the step of random fragmentation into ~100bp long reads (min: 50bp; max: 150bp), generated via my genome.ts script and Sanger institute’s wgsim tool. Then we will use these reads to align them against the reference genome, and in a second step use Megahit to assemble the reads and compare the produced assembly (contigs) to the reference genome.
Summary
Read alignment appears to be accurate. However, as alignment has to be carried out against a reference genome, which is typically identified at first via de-novo assembly, the reliability of the assembly step should be even more important. Here, the de-novo assembly with Megahit - which was used to discover the SARS-CoV-2 genome - shows insufficient reliability in reconstructing entire genomes, as it has failed to reconstruct between 4-7 of the 20 tested reference genomes, including SARS-CoV(-1) and SARS-CoV-2.
@USMortality
Full article: https://usmortality.substack.com/p/how-reliable-is-megahit
Usmortality
How Reliable is Megahit?
A Quality Control Study of the Tools Used to Discover the SARS-CoV-2 Genome
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I’ve enabled comments again, feel free to use this thread for any questions/comments on the last three posts!
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‼️ Based on the latest WHO excess mortality report, we can now conclude that the failed pandemic response has caused almost 2x more excess deaths than COVID-19 deaths world wide!
Based on the presented evidence, one can conclude:
- COVID-19 associated deaths only made up 1/3 of global excess deaths
- COVID-19 associated deaths are vastly over reported and would have never been found significant in absence of flu & without mass testing!
- The vaccines have clearly not ended the excess deaths, and their correlation to peaks of excess deaths is striking.
https://usmortality.substack.com/p/who-admits-excess-deaths
Read more here: https://usmortality.substack.com/p/who-admits-excess-deaths
@USMortality
Based on the presented evidence, one can conclude:
- COVID-19 associated deaths only made up 1/3 of global excess deaths
- COVID-19 associated deaths are vastly over reported and would have never been found significant in absence of flu & without mass testing!
- The vaccines have clearly not ended the excess deaths, and their correlation to peaks of excess deaths is striking.
https://usmortality.substack.com/p/who-admits-excess-deaths
Read more here: https://usmortality.substack.com/p/who-admits-excess-deaths
@USMortality
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PSA: I've now added age group support to Mortality.Watch! Really powerful, as you can select any underlying age group, that's available and used for the ASMR calculation!
—> https://www.mortality.watch
—> https://www.mortality.watch
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