"MATH+ Hospital Treatment Protocol for Covid-19 with detailed guidance on the timing of initiation along with the suggested initial doses and durations of each component medication" - @Covid19Critical
https://t.co/v33PVxEzeg
https://t.co/v33PVxEzeg
Look at the end date on this World Bank Program for Covid19 Investment Project Financing. I say we go for the #MonottiProtocol instead.
LOCKDOWNS ARE A BIG LIE - The EVIDENCE Based SCIENCE: "Stringency of the measures settled to fight pandemia, including LOCKDOWN, DID NOT APPEAR TO BE LINKED WITH DEATH RATE."
https://t.co/5N06jgA0Bg
https://t.co/5N06jgA0Bg
LOCKDOWNS ARE A BIG LIE:
"We explored two MODELS DEVELOPED BY IMPERIAL COLLEGE..Inferences on effects of Non Pharmaceutical Interventions are non-robust and highly sensitive to model specification. CLAIMED BENEFITS OF LOCKDOWN APPEAR GROSSLY EXAGGERATED."
https://t.co/gX6xuQz5EY
"We explored two MODELS DEVELOPED BY IMPERIAL COLLEGE..Inferences on effects of Non Pharmaceutical Interventions are non-robust and highly sensitive to model specification. CLAIMED BENEFITS OF LOCKDOWN APPEAR GROSSLY EXAGGERATED."
https://t.co/gX6xuQz5EY
medRxiv
Effects of non-pharmaceutical interventions on COVID-19: A Tale of Three Models
Objective To compare the inference regarding the effectiveness of the various non-pharmaceutical interventions (NPIs) for COVID-19 obtained from different SIR models.
Study design and setting We explored two models developed by Imperial College that considered…
Study design and setting We explored two models developed by Imperial College that considered…
German doctors created this flyer two months ago. Translation by @pauschgr
Just a quick reminder of why antibiotics are included in early treatment of symptomatic Covid19 (fever):
"Scientists found elevated levels of bacterial debris, bacterial DNA & cell-wall materials, in the blood of those COVID-19 patients with severe cases. The more debris, the sicker the patient —& the more pro-inflammatory substances circulating in the blood.."The findings suggest that in cases of severe COVID-19, bacterial products ordinarily present only in places such as the gut, lungs and throat may make their way into the bloodstream, kick-starting enhanced inflammation that is conveyed to all points via the circulatory system."
https://t.co/9Upd8sv1Rr
https://t.co/9Upd8sv1Rr
News Center
Study reveals immune-system deviations in severe COVID-19 cases
A Stanford study shows that in severely ill COVID-19 patients, “first-responder” immune cells, which should react immediately to signs of viruses or bacteria in the body, instead respond sluggishly.
Even WHO guidance indicates this, it clearly does indicate both the risks of bacterial infection & to prescribe broad spectrum antibiotics as part of treatment:
"Collect blood cultures for bacteria that cause pneumonia and sepsis, ideally before antimicrobial therapy. DO NOT
delay antimicrobial therapy..
"6. Management of severe COVID-19: treatment of co-infections
Give empiric antimicrobials [broad spectrum antibiotics] to treat all likely pathogens causing SARI and sepsis as soon as possible, within 1 hour
of initial assessment for patients with sepsis.
"Empiric antibiotic treatment should be based on the clinical diagnosis (community-acquired
pneumonia, health care-associated pneumonia [if infection was acquired in health care setting] or sepsis), local epidemiology &
susceptibility data, and national treatment guidelines"
(On the 19th March 2020 the WHO released this guidance intended for healthcare workers (HCWs), healthcare managers and IPC teams at the facility level & at national and district/provincial level:
https://t.co/C4aV2BnMPj)
"Collect blood cultures for bacteria that cause pneumonia and sepsis, ideally before antimicrobial therapy. DO NOT
delay antimicrobial therapy..
"6. Management of severe COVID-19: treatment of co-infections
Give empiric antimicrobials [broad spectrum antibiotics] to treat all likely pathogens causing SARI and sepsis as soon as possible, within 1 hour
of initial assessment for patients with sepsis.
"Empiric antibiotic treatment should be based on the clinical diagnosis (community-acquired
pneumonia, health care-associated pneumonia [if infection was acquired in health care setting] or sepsis), local epidemiology &
susceptibility data, and national treatment guidelines"
(On the 19th March 2020 the WHO released this guidance intended for healthcare workers (HCWs), healthcare managers and IPC teams at the facility level & at national and district/provincial level:
https://t.co/C4aV2BnMPj)
IVERMECTIN "As expected for an effective treatment, early treatment is more successful, with an estimated reduction of 87% in the effect measured using a random effects meta-analysis"
https://t.co/Y1vIMjb2AG
https://t.co/Y1vIMjb2AG
Ivmmeta
Ivermectin for COVID-19: real-time meta analysis of 60 studies
Ivermectin for COVID-19. Early treatment - 76% improvement, p < 0.0001. All studies - 71% improvement, p < 0.0001. 1 in 2 trillion probability results of the 60 studies are from an ineffective treatment (p = 4.5e-13).
"Ivermectin reduces the risk of death from COVID-19 - A rapid review and meta-analysis in support of the recommendation of the Front Line COVID-19 Critical Care Alliance" https://www.e-bmc.co.uk/
E-BMC
Research for impact | E-BMC
Evidence-based medical research. Evidence synthesis, research support, clinical trial protocols, guideline development, Cochrane, and other systematic reviews.
"Antiviral Activity of Ivermectin Against SARS-CoV-2: An Old-Fashioned Dog with a New Trick - A Literature Review"
https://www.researchgate.net/publication/343689933_Antiviral_Activity_of_Ivermectin_Against_SARS-CoV-2_An_Old-Fashioned_Dog_with_a_New_Trick_-_A_Literature_Review
https://www.researchgate.net/publication/343689933_Antiviral_Activity_of_Ivermectin_Against_SARS-CoV-2_An_Old-Fashioned_Dog_with_a_New_Trick_-_A_Literature_Review
The timing of lockdowns is not determined by the virus, but by how long it takes the Federal Reserve, the European Central Bank, & the Bank of England to roll out their government backed cryptocurrencies. This is because they are competing with China which already implemented it.
China’s digital yuan currency is designed primarily to prevent the dominance of the US dollar, rather than address threats raised by cryptocurrencies:
https://t.co/QYw3DlQkgI
https://t.co/QYw3DlQkgI
South China Morning Post
China’s digital yuan aims to halt US ‘dollarisation’, boost retail payments
Former central bank governor Zhou Xiaochuan says China’s digital currency plan is focused on preventing US dollar hegemony and building up domestic retail payments.
The timing of lockdowns is not determined by the virus, but by how long it takes the Federal Reserve, the European Central Bank, & the Bank of England to roll out their government backed digital currencies.
What to do? Hold silver, gold & bricks & mortar long term, cash short term outside of the bank, however cash will lose value & lockdowns will prevent you from spending cash. Once government digital currencies are rolled out governments will destroy cryptocurrencies with all means IMHO.
Seasonality of Respiratory Viral Infections
Annual Review of Virology
(SARSCoV2 is a HCoV)
https://www.annualreviews.org/doi/10.1146/annurev-virology-012420-022445
Annual Review of Virology
(SARSCoV2 is a HCoV)
https://www.annualreviews.org/doi/10.1146/annurev-virology-012420-022445