⬆️ The effectiveness of Neurocognitive Rehab (shared by Dr. Akbar-Fahimi/Ms. Zamani)
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⬆️⬆️ Dear All, We got agreement with the NBML for shared initiatives and projects. Please go through this and propose your ideas if any. NSL_Shiraz and the NBML are likely to enjoy shared interests. Awaiting you inputs.
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🔽 لطفا فرم های پر شده را به کارشناس محترم NSL سرکار خانم صفایی ارایه بفرمایید.
Forwarded from آزمایشگاه علوم اعصاب NSL
We got agreement with the NBML for shared initiatives and projects
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infantile amnesia reflects a developmental critical period for hippocampal learning
Episodic memories formed during the first postnatal period are rapidly forgotten, a phenomenon known as 'infantile amnesia'. In spite of this memory loss, early experiences influence adult behavior, raising the question of which mechanisms underlie infantile memories and amnesia. Here we show that in rats an experience learned during the infantile amnesia period is stored as a latent memory trace for a long time; indeed, a later reminder reinstates a robust, context-specific and long-lasting memory. The formation and storage of this latent memory requires the hippocampus, follows a sharp temporal boundary and occurs through mechanisms typical of developmental critical periods, including the expression switch of the NMDA receptor subunits from 2B to 2A, which is dependent on brain-derived neurotrophic factor (BDNF) and metabotropic glutamate receptor 5 (mGluR5). Activating BDNF or mGluR5 after training rescues the infantile amnesia. Thus, early episodic memories are not lost but remain stored long term. These data suggest that the hippocampus undergoes a developmental critical period to become functionally competent.
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https://www.nature.com/neuro/journal/v19/n9/full/nn.4348.html
infantile amnesia reflects a developmental critical period for hippocampal learning
Episodic memories formed during the first postnatal period are rapidly forgotten, a phenomenon known as 'infantile amnesia'. In spite of this memory loss, early experiences influence adult behavior, raising the question of which mechanisms underlie infantile memories and amnesia. Here we show that in rats an experience learned during the infantile amnesia period is stored as a latent memory trace for a long time; indeed, a later reminder reinstates a robust, context-specific and long-lasting memory. The formation and storage of this latent memory requires the hippocampus, follows a sharp temporal boundary and occurs through mechanisms typical of developmental critical periods, including the expression switch of the NMDA receptor subunits from 2B to 2A, which is dependent on brain-derived neurotrophic factor (BDNF) and metabotropic glutamate receptor 5 (mGluR5). Activating BDNF or mGluR5 after training rescues the infantile amnesia. Thus, early episodic memories are not lost but remain stored long term. These data suggest that the hippocampus undergoes a developmental critical period to become functionally competent.
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https://www.nature.com/neuro/journal/v19/n9/full/nn.4348.html
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Flexible information routing by transient synchrony
Perception, cognition and behavior rely on flexible communication between microcircuits in distinct cortical regions. The mechanisms underlying rapid information rerouting between such microcircuits are still unknown. It has been proposed that changing patterns of coherence between local gamma rhythms support flexible information rerouting. The stochastic and transient nature of gamma oscillations in vivo, however, is hard to reconcile with such a function. Here we show that models of cortical circuits near the onset of oscillatory synchrony selectively route input signals despite the short duration of gamma bursts and the irregularity of neuronal firing. In canonical multiarea circuits, we find that gamma bursts spontaneously arise with matched timing and frequency and that they organize information flow by large-scale routing states. Specific self-organized routing states can be induced by minor modulations of background activity.
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https://www.nature.com/neuro/journal/v20/n7/full/nn.4569.html
Flexible information routing by transient synchrony
Perception, cognition and behavior rely on flexible communication between microcircuits in distinct cortical regions. The mechanisms underlying rapid information rerouting between such microcircuits are still unknown. It has been proposed that changing patterns of coherence between local gamma rhythms support flexible information rerouting. The stochastic and transient nature of gamma oscillations in vivo, however, is hard to reconcile with such a function. Here we show that models of cortical circuits near the onset of oscillatory synchrony selectively route input signals despite the short duration of gamma bursts and the irregularity of neuronal firing. In canonical multiarea circuits, we find that gamma bursts spontaneously arise with matched timing and frequency and that they organize information flow by large-scale routing states. Specific self-organized routing states can be induced by minor modulations of background activity.
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https://www.nature.com/neuro/journal/v20/n7/full/nn.4569.html
This weeks' SCIENCE issue https://www.sciencemagazinedigital.org/sciencemagazine/30_june_2017?sub_id=45PS8xPODtVD&u1=41653155&pg=1#pg1 Check out pages 1352, 1379 and 1383
www.sciencemagazinedigital.org
Science Magazine - June 30, 2017 - 1
Forwarded from آزمایشگاه علوم اعصاب NSL
NSL AAAS Membership.pdf
408.8 KB
https://www.scilit.net/journals/547534 JAMSAT is now indexed with Scilit (CASRP; Center of Advanced Scientific Research and Publications).
Forwarded from آزمایشگاه علوم اعصاب NSL
🔼جهت هماهنگی، تسهیل ثبت نام و شرکت در کارگاه با سرکار خانم ایمانی مسوول هماهنگی کارگاه ها در NSL تماس حاصل فرمایید. 07132305471 داخلی 118
Using serious video gaming to enhance social interaction. A good watch...